Use of different exhaled nitric oxide multiple flow rate models in COPD

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Use of different exhaled nitric oxide multiple flow rate models in COPD.

Multiple flow rates of exhaled nitric oxide (eNO) fraction (F(e,NO)) data can be modelled to estimate airway wall concentration of nitric oxide (C(aw,NO)), diffusing capacity of nitric oxide (D(aw,NO)), alveolar nitric oxide concentration (C(alv,NO)) and total maximal flux of nitric oxide in the airway compartment (J'(aw,NO)). F(e,NO) at 10, 30, 50, 100 and 200 mL.s(-1) from 50 chronic obstruct...

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Exhaled nitric oxide and COPD.

We were interested to read the paper by LEHTIMÄKI et al. [1] recently published in the European Respiratory Journal, in which those authors reported that ‘‘high pre-treatment levels of J9aw,NO [bronchial nitric oxide flux] are related to symptom relief and improvement of airway obstruction’’ when inhaled fluticasone is given to patients with chronic obstructive pulmonary disease (COPD). Their d...

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Repeatability of exhaled nitric oxide measurements in patients with COPD

The assessment of the presence of eosinophilic airway inflammation may help in predicting the steroid response in subjects with respiratory symptoms. Unlike patients with asthma, only a subset of patients with chronic obstructive pulmonary disease (COPD) benefits from steroid treatment. Fractional exhaled nitric oxide (FENO) is a useful surrogate marker for eosinophilic airway inflammation, but...

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Exhaled nitric oxide in COPD: glancing through a smoke screen.

There is worldwide increasing awareness of the human and socioeconomic impact of chronic obstructive pulmonary disease (COPD) which is a major cause of morbidity and mortality. Even though its pathogenesis in industrialised countries is linked to a well known cause—namely, tobacco smoking—it is not envisaged that this knowledge will lead to breakthroughs in the prevention of this disease during...

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Exhaled nitric oxide from lung periphery is increased in COPD.

Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers a...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2007

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00149706